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The Power of Exercise: Countering Major Genetic Risk for Type 2 Diabetes


New Research has found a strong link between high levels of physical activity and a reduced risk of type 2 diabetes, even in individuals with a high genetic predisposition to the disease. The study, included 59,325 UK biobank participants whoof thearmIn a study followed for seven years by a wearable accelerometer, it was found that an hour or more of moderate-intensity physical activity per day was associated with a 74 percent reduction in type 2 diabetes. Risk compared to less active individuals,

Can physical activity 'fight' the risk of type 2 diabetes?  

One of the University of SydneySurveyshows that high levels of physical activity can significantly reduce the risk of type 2 diabetes, even for people with a high genetic risk. Moderate-to-vigorous exercise of more than one hour per day was associated with a 74 percent reduction in the risk of type 2 diabetes, which is similar to physical activity in preventing the condition.AttitudesEmphasizes.

New research has shown that being active can significantly reduce the risk of type 2 diabetes, even in people who have a high genetic risk of developing the condition.

Research led by the University of Sydney found that higher levels of total physical activity, particularly moderate to vigorous-intensity physical activity, were strongly associated with a lower risk of type 2 diabetes.

The results were published on June 5.British Journal of Sports Medicine.

Researchers say the study shows that high levels of physical activity should be promoted as a major strategy to prevent type 2 diabetes, which millions of Australians are suffering from.EffectiveThere are.

The new study involved 59,325 adults from the UK Biobank.، who wore accelerometers (activity trackers worn on their wrists) at the start of the study and then followed them for seven years to track health outcomes. Monitoring done

UK Biobank is a large-scale biomedical database and research resource containing UK biomedical records halfIncludes anonymous genetic, lifestyle, and health information from millions of participants.

It has a higher risk of developing type 2 diabetesAttachmentsGenetic markers were included. People with a high genetic risk score had a 2.4-fold increased risk of developing type 2 diabetes when compared to those with lower genetic risk scores.

The study found that more than an hour of moderate-to-vigorous physical activity per day was associated with a 74 percent lower risk of developing type 2 diabetes than participants who did less than 5 minutes of physical activity.

when other factors, including genetic risk, were taken into account.

Another striking finding was that participants who had a high genetic risk, but who were in the most physically active category, had a lower risk of developing type 2 diabetes than those with a low genetic risk. But in the least active category.

"Although the role of genetics and physical activity in the onset of type 2 diabetes is well established, until now most of the data has been self-reported," says senior author Associate Professor Melody Ding from the Charles Perkins Center and Faculty of Medicine and Health. There was and was very little. Evidence on whether genetic risk can be counteracted by physical activity.

"We are unable to control our genetic risk and family history, but this finding provides promising and positive news that through an active lifestyle, one can 'combat' the very high risk of type 2 diabetes. Is."

Associate Professor Ding says moderate physical activity describes activities that make you sweat and get out of breath a bit, such as brisk walking and general gardening.

-Examples of vigorous physical activity include running, aerobic dance, cycling uphill or at high speeds, and heavy gardening such as digging - all activities that stop you breathing or cause you to breathe heavily.

Diabetes is a global public health problem. In 2021, 537 million adults worldwide were living with diabetes. 1.2 million Australians were recorded as living with type 2 diabetes in 2020.

The findings also have a strong personal meaning for Associate Professor Ding, whose father was recently diagnosed with type 2 diabetes in his sixties.

"My father's family has a history of type 2 diabetes, so the result of the study is extremely gratifying for me and my family. As an already active person, I now have this active lifestyle," says Associate Professor Ding. There is additional motivation to sustain life.

"Our hope is that this study will inform public health and clinical guidelines to help health professionals prevent chronic diseases."

"I'm excited to share my cutting-edge research findings with audiences to inform people that physical activity improves health, especially for those with a higher genetic risk. If "If you have a family history of type 2 diabetes, or if you don't, today is the day to be physically active," says Ph.D. candidate Mengyun (Susan) Luo, who led the study.

Reference: "Accelerometer Measured Intensity-Specific Physical Activity, Genetic Risk and Incident Type 2 Diabetes: A Prospective Cohort Study" by Mengyun Luo, Chenhao Yu, Borja Del Pozo Cruz, Liangkai Chen and Ding Ding, June 5, 2023, British Journal of Sports Medicine.

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